Tatsushi Toda Selected Research

Walker-Warburg Syndrome

10/2021	Restoration of the defect in radial glial fiber migration and cortical plate organization in a brain organoid model of Fukuyama muscular dystrophy.
1/2018	Temporal requirement of dystroglycan glycosylation during brain development and rescue of severe cortical dysplasia via gene delivery in the fetal stage.
1/2016	Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of α-dystroglycan.
10/2015	Founder mutation causes classical Fukuyama congenital muscular dystrophy (FCMD) in Chinese patients.
2/2015	Fukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expression.
1/2014	Contribution of dysferlin deficiency to skeletal muscle pathology in asymptomatic and severe dystroglycanopathy models: generation of a new model for Fukuyama congenital muscular dystrophy.
8/2013	Novel POMGnT1 mutations cause muscle-eye-brain disease in Chinese patients.
4/2013	[Fukuyama muscular dystrophy: elucidation of the gene and pathogenesis and approaches toward molecular targeting therapy].
7/2012	Detection of the dystroglycanopathy protein, fukutin, using a new panel of site-specific monoclonal antibodies.
1/2012	[Molecular targeting therapy for Fukuyama muscular dystrophy].

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Tatsushi Toda Research Topics

Disease

39	Muscular Dystrophies (Muscular Dystrophy) 01/2022 - 03/2002
26	Walker-Warburg Syndrome 10/2021 - 03/2002
25	Parkinson Disease (Parkinson's Disease) 01/2022 - 01/2002
18	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 06/2003
12	Alzheimer Disease (Alzheimer's Disease) 09/2021 - 01/2005
9	Huntington Disease (Huntington's Disease) 01/2020 - 06/2003
6	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 02/2022 - 03/2013
6	Muscular Diseases (Myopathy) 01/2022 - 01/2012
6	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2020 - 04/2007
5	Myositis (Idiopathic Inflammatory Myopathies) 01/2022 - 05/2013
5	Stroke (Strokes) 05/2020 - 01/2013
4	Muscle Weakness 01/2022 - 01/2015
4	Neoplasms (Cancer) 01/2022 - 08/2012
4	Epilepsy (Aura) 09/2021 - 03/2013
4	Dementia (Dementias) 01/2021 - 08/2006
4	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 01/2020 - 01/2005
4	Parkinsonian Disorders (Parkinsonism) 01/2019 - 02/2006
4	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 07/2012 - 02/2009
3	Amyloidosis 07/2022 - 01/2012
3	Polymyositis 01/2022 - 01/2019
3	Drug-Related Side Effects and Adverse Reactions 01/2022 - 10/2019
3	COVID-19 10/2021 - 05/2020
3	Autoimmune Diseases (Autoimmune Disease) 05/2020 - 01/2013
3	Atrophy 02/2018 - 08/2005
3	Heart Failure 10/2017 - 05/2013
3	Eye Abnormalities (Eye Abnormality) 10/2010 - 07/2003
2	Chronic Kidney Failure (Chronic Renal Failure) 07/2022 - 09/2014
2	Mitochondrial Diseases (Mitochondrial Disease) 07/2022 - 01/2021
2	Inflammation (Inflammations) 07/2022 - 11/2019
2	Thymoma (Thymic Carcinoma) 05/2022 - 01/2019
2	Inclusion Body Myositis 01/2022 - 01/2020
2	Takotsubo Cardiomyopathy 01/2022 - 01/2022
2	Multiple Sclerosis 01/2022 - 01/2015
2	Fibrosis (Cirrhosis) 01/2021 - 11/2019
2	Psychotic Disorders (Schizoaffective Disorder) 05/2020 - 08/2006
2	Mitochondrial Myopathies (Mitochondrial Myopathy) 01/2020 - 01/2018
2	X-Linked Bulbo-Spinal Atrophy 01/2020 - 04/2007
2	Encephalitis (Encephalitis, Rasmussen) 10/2019 - 03/2011
2	Cognitive Dysfunction 01/2019 - 01/2019
2	Hypertension (High Blood Pressure) 11/2018 - 10/2017
2	Diabetes Mellitus 11/2018 - 10/2017
2	Melanoma (Melanoma, Malignant) 11/2018 - 08/2012
2	Malformations of Cortical Development 01/2018 - 06/2005
2	Atrial Fibrillation 10/2017 - 05/2013
2	Febrile Seizures (Febrile Seizure) 10/2015 - 01/2008
2	Neuromyelitis Optica (Devic's Disease) 01/2013 - 03/2011
1	Proteinuria 07/2022
1	1 Rippling muscle disease 05/2022
1	Bronchogenic Cyst 05/2022

Drug/Important Bio-Agent (IBA)

32	Dystroglycans (Dystroglycan)IBA 01/2022 - 03/2002
24	Proteins (Proteins, Gene)FDA Link 01/2020 - 03/2003
17	polyglutamineIBA 01/2020 - 06/2003
10	protein O-mannose beta-1,2-N-acetylglucosaminyltransferaseIBA 01/2016 - 03/2002
7	Laminin (Merosin)IBA 01/2018 - 06/2003
7	LigandsIBA 10/2016 - 07/2003
6	AntibodiesIBA 05/2022 - 05/2013
6	AutoantibodiesIBA 01/2022 - 03/2011
6	RibitolIBA 01/2022 - 03/2016
6	Polysaccharides (Glycans)IBA 01/2020 - 08/2012
6	GlycosyltransferasesIBA 01/2016 - 04/2006
5	Phosphates (Orthophosphate)IBA 01/2022 - 03/2016
5	Amyloid (Amyloid Fibrils)IBA 01/2021 - 08/2007
4	Creatine Kinase (Creatine Phosphokinase)IBA 01/2022 - 05/2013
4	EnzymesIBA 01/2022 - 01/2006
4	Peptides (Polypeptides)IBA 01/2020 - 01/2005
4	Pharmaceutical PreparationsIBA 01/2020 - 04/2013
4	alpha-SynucleinIBA 01/2019 - 02/2006
4	NucleotidesIBA 03/2015 - 08/2005
3	Cholinergic ReceptorsIBA 05/2022 - 04/2006
3	Glucose (Dextrose)FDA LinkGeneric 05/2020 - 03/2017
3	Immune Checkpoint InhibitorsIBA 01/2020 - 01/2019
3	Triglycerides (Triacylglycerol)IBA 01/2018 - 01/2014
3	Complementary DNA (cDNA)IBA 11/2007 - 03/2003
2	Lactic Acid (Lactate)FDA LinkGeneric 07/2022 - 01/2020
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2022
2	Adrenergic Agonists (Adrenergic Receptor Agonist)IBA 01/2022 - 01/2022
2	CholesterolIBA 01/2022 - 01/2022
2	Zonisamide (Zonegran)FDA LinkGeneric 01/2022 - 08/2020
2	Arginine (L-Arginine)FDA Link 01/2022 - 01/2020
2	Mitochondrial DNA (mtDNA)IBA 01/2021 - 01/2015
2	Acetazolamide (Diamox)FDA LinkGeneric 01/2021 - 09/2014
2	Levodopa (L Dopa)FDA LinkGeneric 08/2020 - 01/2015
2	Biomarkers (Surrogate Marker)IBA 07/2020 - 01/2019
2	SodiumIBA 05/2020 - 09/2018
2	TransferasesIBA 01/2020 - 01/2018
2	GadoliniumIBA 01/2020 - 11/2019
2	SynucleinsIBA 10/2018 - 11/2013
2	Indicators and Reagents (Reagents)IBA 03/2018 - 07/2003
2	Retinaldehyde (Retinal)IBA 02/2018 - 08/2008
2	DystrophinIBA 04/2016 - 01/2006
2	Mannose (D-Mannose)IBA 01/2016 - 10/2010
2	DNA (Deoxyribonucleic Acid)IBA 03/2015 - 01/2015
2	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2015 - 08/2014
2	Nonsense Codon (Nonsense Mutation)IBA 07/2014 - 01/2008
2	Aquaporins (Water Channels)IBA 01/2013 - 03/2011
2	Aquaporin 4IBA 01/2013 - 03/2011
2	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 08/2008 - 06/2007
1	canakinumab FDA Link 07/2022
1	Pyruvic Acid (Pyruvate)IBA 07/2022

Therapy/Procedure

7	Therapeutics 01/2022 - 01/2012